ER stress and neurodegenerative diseases

By D. Lindholm, Hanna Wootz, L. Korhonen. Cell Death and Differentiation, 2006

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Calcium and neurodegeneration (2007, background): “Calpains may also play an important role in the triggering of apoptotic cascades by virtue of their ability to activate caspases (Leist et al ., 1997; Stefanis, 2005).”
ER chaperones in mammalian development and human diseases (2007, background): “neurodegenerative disorders characterized by accumulation of the misfolded form of the cellular prion protein (PrP), denoted PrP (scrapie-associated PrP), and consequent neuronal dysfunction and death [64].”
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword? (2007, positive): “…of ER stress markers has been demonstrated in post-mortem brain tissues and cell-culture models of many neu-MALHOTRA rodegenerative disorders, including PD, AD, amyotropic lateral sclerosis (ALS), and expanded polyglutamine diseases such as Huntington disease and spinocerebellar ataxias (77).”
Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. (2013, background): “Pesticides have reserved the most prominent role in the most of the surveys focusing on the association of environmental and occupational exposures with ALS, which have been carried out up to now, and it would not be unlikely to consider them as a risk factor for developing this neurological disorde”