A viral microRNA functions as an orthologue of cellular miR-155

By E. Gottwein, Neelanjan Mukherjee, C. Sachse, Corina Frenzel, William H. Majoros, J. Chi, Ravi Braich, M. Manoharan, J. Soutschek, Uwe Ohler and 1 more. Nature, 2007

613 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/46ae7815b995c828fa22b7d12f4699ad403c3053

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Citations in the corpus

Physiological and pathological roles for microRNAs in the immune system (2010, background): “In a similar manner, a viral orthologue of miR-155 encoded by KSHV (miR-K12-11) can have growth-promoting effects on cells and lead to KSHV-induced tumours, especially in patients with immunodeficienc”
MicroRNAs in development and disease. (2011, background): “One of the most intriguing KSHV miRNAs is miR-K11 (miR-K12–11), which is an ortholog of mammalian miR155 (211, 564).”
The Role of MicroRNAs in Human Diseases (2010, background): “Also, miR-K12-11 encoded by the Kaposi’s-sarcoma-associated herpes virus, has been reported to down-regulate the expression of numerous similar cellular target mRNAs (163) .”
MicroRNAs: new regulators of immune cell development and function (2008, background): “Furthermore, transforming B cell–tropic viruses can either express orthologs of miR-155, as noted with Kaposi's sarcoma viru”
miR-155 gene: a typical multifunctional microRNA. (2009, background): “Gottwein and colleagues showed that a miRNA encoded by Kaposi’s-sarcoma-associated herpes virus (KSHV) known as miR-K12-11, functions as an orthologue of cellular miR-155 providing a replicative advantage to the KHSV through the down regulation of the expression of genes with known roles in cell gro”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “Kaposi's sarcoma-associated herpes virus is homologous to miR-155 [25].”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “1) One of the viral latent transcripts in primary effusion lymophoma cells, miRNA-K12–11, has been found to target the same cellular microRNAs as miRNA-155, a cellular microRNA regulating the germinal centre reaction during B-cell maturation (Gottwein et al., 2007; Skalsky et al., 2007; Thai et al.,”
MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA (2008, background): “Two recent studies using gene expression microarray analyses showed that miR155 and its viral orthologue Kaposi’s sarcoma-associated herpesvirus miR-K12-11 negatively regulate more than 180 mRNAs, some of which encode proteins involved in cell migration and invasion, including GSK3, PCSK5, and Rho G”
Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals (2009, background): “S4B) and was significantly inhibited by miR-155, in agreement with previous reports (19) (Fig.”
MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011, background): “Analysis of both miR-155 and its Kaposi's sarcoma-associated herpesvirus (KSHV) homologue has identified IKKɛ as a potential target, which supports the notion that miR-155 can negatively regulate innate immune signallin”
microRNA regulation of inflammatory responses. (2012, background): “Interestingly, Kaposi’s sarcomaassociated herpesvirus (KSHV) encodes an ortholog of miR-155 that has an identical seed sequence and targets overlapping gene subsets (71).”
MicroRNAs in Common Human Diseases (2012, background): “Interestingly, these two miRNAs target the same set of cellular genes, indicating a similar function [71].”