Hsp90 as a capacitor of phenotypic variation
By C. Queitsch, Todd A. Sangster, Susan Lindquist. Nature, 2002
1,411 citations recorded by the source corpus.
Subfields: Aging, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4639c4224020457eb2a786672ed1976589dc1565
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
In Molecular Biology
- Joanna Masel
- Alexander van Oudenaarden
- Arjun Raj
- M. Siegal
- M. Pigliucci
- Thomas F. Hansen
- Mikko Taipale
- J. G. Sørensen
Citations in the corpus
- Is evolvability evolvable? (2008, background): “Intriguing experimental work with systems such as the ubiquitous Hsp90 heat-shock protein”
- Robustness and evolvability: a paradox resolved (2008, background): “…show that many organisms harbour cryptic genetic variation—reflecting robustness—which can become visible in certain environments or genetic backgrounds, and thus lead to enhanced evolvability (Waddington 1953; Dun & Fraser 1959; Waddington 1959; Rutherford & Lindquist 1998; Queitsch et al. 2002).”
- A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors (2003, background): “Thus, Hsp90 may serve an analogous role in the somatic evolution of tumours as in darwinian evolutio”
- Stochastic gene expression and its consequences (2008, background): “However, one excellent example of a developmental buffer against noise is the activity of Hsp90 in Arabidopsis (Queitsch et al., 2002), the inhibition of which reveals the effects of genetic and environmental variability.”
- Canalization of development by microRNAs (2006, background): “Canalization is thought to be mediated by the buffering activity of specific genes; however, with the one notable exception of hsp90 (refs”
- Robustness: mechanisms and consequences (2009, background): “Examples include perturbation of translation termination by the yeast prion [PSI+] [63–65] (Box 3), and the heat shock protein Hsp90, which affects a stunning variety of developmental processes [8,66].”
- Application of heat shock protein expression for detecting natural adaptation and exposure to stress in natural populations (2010, background): “Laboratory studies show that very small amounts of induced HSPs can have effects on life history traits such as development, stress resistance, life span and fecundity (Rutherford and Lindquist, 1998; Sørensen and Loeschcke, 2001; Queitsch et al., 2002; Rutherford, 2003).”