Robustness and evolvability: a paradox resolved

By Andreas Wagner. Proceedings of the Royal Society of London. Biological Sciences, 2008

670 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/462457c5cdab45eaf410fa3076ffe87d3ed79698

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Citations in the corpus

What Evolvability Really Is (2014, neutral): “(Wagner and Altenberg [1996]); (Wagner [2008]) (2) The capacity of the individuals within a population for adaptive phenotypic plasticity.”
Robustness and Evolvability (2010, background): “However, increased robustness can still facilitate evolvability in the low mutation case when robust populations explore their neutral networks more quickly than low-robustness populations [16].”
Evolvability Is Inevitable: Increasing Evolvability without the Pressure to Adapt (2013, background): “Although the cause of such increase is still debated, most candidate explanations for evolvability rely on selection pressure [1–8], reflecting natural selection’s significant explanatory power in other contexts.”
Evolvability as a function of purifying selection in TEM-1 β-lactamase. (2015, positive): “For example, recent studies (Draghi et al., 2010; Hayden et al., 2011; Payne and Wagner, 2014; Wagner, 2008) show that robustness can facilitate the adaptation of biological systems to environmental change—a property sometimes called ''evolvability'' (Kirschner and Gerhart, 1998).”
Enzyme promiscuity: a mechanistic and evolutionary perspective. (2010, background): “These two features may appear to be conflicting: Can mutations simultaneously induce no phenotypic changes and significant changes? It appears that biological systems, including proteins, exhibit both traits, namely plasticity and robustness, and the two are not necessarily mutually exclusive (51, 1”
Neutralism and selectionism: a network-based reconciliation (2008, background): “This question has recently been addressed in a computational study using RNA secondary structures as phenotype”
Exploring protein fitness landscapes by directed evolution (2009, positive): “For example, the introduction of stabilizing mutations can increase a protein's mutational robustness, opening new routes for further adaptatio”
Towards a Developmental Turn in Evolutionary Economic Geography? (2015, background): “It is the interplay between developmental robustness and developmental plasticity that shapes the pace and direction of evolutionary change (WAGNER, 2008).”