Siblings, day-care attendance, and the risk of asthma and wheezing during childhood.

By T. Ball, J. Castro-Rodriguez, Kent A. Griffith, C. Holberg, F. D. Martinez, A. Wright. New England Journal of Medicine, 2000

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The germless theory of allergic disease: revisiting the hygiene hypothesis (2001, background): “Similar effects have been noted for early day-care attendanc”
Asthma: an epidemic of dysregulated immunity (2002, background): “as well as studies showing that early placement in day care settings, and presumed exposure to infectious agents, appears to protect against the development of asthm”
Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report (2007, background): “hepatitis A, measles), mycobacteria or parasites, may reduce the incidence of allergy and/or asthma (33–35), and that recurrent mild infections may protect against asthma (36, 37).”
Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “The mechanism by which Nod1 variants increase the susceptibility to these allergic diseases is unknown, but it might be explained through the interaction of the host with the microbial environment during childhood, which is known to protect against the development of disease (129, 130).”