The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
By A. Elia, P. Rellos, L. Haire, Jerry W. Chao, Frank J. Ivins, K. Hoepker, Duaa H. Mohammad, Lewis C. Cantley, S. Smerdon, Michael B. Yaffe. Cell, 2003
791 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/45aab1bbb6ace745f37ed22c04aefd63af66cfe8
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Citations in the corpus
- Shared and separate functions of polo-like kinases and aurora kinases in cancer (2010, background): “The PBD can serve as a phospho-dependent docking motif that brings the kinase into close proximity to its substrate, and priming phosphorylation of Plk1 substrates by either cyclin-dependent kinase 1 (CDK1) or PLK1 itself promotes the interaction between PLK1 and its substrate”
- Targeting polo-like kinase 1 for cancer therapy (2006, background): “The crystal structures of the PLK1 C-terminus also showed that the PBD comprises two β 6 α motifs, which correspond to the two polo-box region”
- Polo-like kinases and the orchestration of cell division (2004, background): “sapiens PLK1 illustrates how phosphopeptides can bind to an interface that is formed between the two polo boxe”