Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

By S. Vaynman, Z. Ying, F. Gomez-Pinilla. European Journal of Neuroscience, 2004

1,491 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/458b8d5567289f98aeb00a1d6b80104bab6c91de

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Citations in the corpus

Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function. (2007, background): “In rodents, voluntary exercise enhances the rate of learning on swimming tasks, such as the Morris Water maze, that require the use of extra-maze cues to determine the location of a submerged platform [30, 31 ].”
High impact running improves learning. (2007, background): “exercise and learning improvement (Cotman & Berchtold, 2002; Vaynman et al., 2004).”
A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children (2010, positive): “…old age (van Praag et al., 1999, 2005; Eadie et al., 2005), enhance hippocampal-dependent learning and memory processes (Forordyce and Wehner, 1993; Vaynman et al., 2004; van Praag et al., 2005), and increase hippocampal levels of brain-derived neurotrophic factor (BDNF), insulin-like growth…”
Plasticity of Brain Networks in a Randomized Intervention Trial of Exercise Training in Older Adults (2010, positive): “The precise neurobiological mechanism for such cognitive effects remains unknown, however a vast rodent literature supports a central role of protective neurotrophins such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor (IGF-1) (Neeper et al., 1”
The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review (2016, neutral): “memory [260], pattern separation [261], object recog-”
Exercise is the real polypill. (2013, background): “Increased BDNF transcripts in exercised rodents’ brains are well documented, providing mechanistic support for a beneficial exercise effect in cognitive function (4, 5, 30, 153, 193, 275, 315, 333, 334, 352, 396, 417, 425, 460, 488, 507), e.”
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, methodology): “More- over, increased level of BDNF in mouse hippocampus evoked by voluntary exercises correlated with improved performance in the Morris water maze test and behavioral tasks related to learning (Vaynman et al. 2004).”
Aerobic Fitness is Associated With Hippocampal Volume in Elderly Humans (2009, positive): “…synaptic plasticity (Farmer et al., 2004; Christie et al., 2008), and enhances hippocampal-dependent learning and memory processes as assessed by Morris water maze and radial arm maze performance (Fordyce and Wehner, 1993; Anderson et al., 2000; Vaynman et al., 2004; Van Praag et al., 2005).”
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways (2006, neutral): “, 2004 ; Vaynman et al .”
Effects of Physical Exercise on Cognitive Functioning and Wellbeing: Biological and Psychological Benefits (2018, background): “…al., 1992; Kleim et al., 2002; Swain et al., 2003; Ekstrand et al., 2008; Gelfo et al., 2018; [3] Lista and Sorrentino, 2010; Lin and Kuo, 2013; [4] Vaynman et al., 2004; van Praag, 2009; Lafenetre et al., 2011; Coelho et al., 2013; [5] van Praag et al., 2005; Nithianantharajah and Hannan, 2006;…”
Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “, and this increase in BDNF may improve hippocampus-based learning, synaptic plasticity and neurogenesi”
Effects of Aerobic Exercise on Mild Cognitive Impairment (2010, neutral): “on memory have been reported in a few clinical trials,(20,21) although most support for a memory benefit comes from animal research.(8,11,22,23) In humans, results of crosssectional(24) and prospective(25) brain imaging studies suggest that increased aerobic fitness in cognitively healthy older adul”
Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta‐analysis (2018, positive): “This is an open access article unde Changes in hippocampal structure may be mediated by trophic factors, such as insulin-like growth factor 1 (IGF-1) and brain-derived neurotrophic factor (BDNF) (Ferris et al., 2007; Vaynman et al., 2004).”