Astrocytes promote myelination in response to electrical impulses.

By T. Ishibashi, K. Dakin, Beth Stevens, Philip Lee, Serguei Kozlov, C. L. Stewart, R. D. Fields. Neuron, 2006

699 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/452f69da827350cd1b6f0d7ab85281106aee2781

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Citations in the corpus

Axon-glial signaling and the glial support of axon function. (2008, background): “…that the activitydependent release of ATP from axons in the CNS stimulates nearby astrocytes to release the cytokine leukemia inhibiting factor, which in turn stimulates oligodendrocyte myelination (Ishibashi et al. 2006), and defects in this tripartite pathway may cause dysmyelination.”
Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved (2007, background): “In addition to their involvement in the initial phase of the inflammatory response, IL-6 and LIF could also directly and/or indirectly influence neuronal survival and myelination (Marz et al., 1999; Ishibashi et al., 2006).”
The Development of Brain White Matter Microstructure (2018, background): “This ontogenic pattern is tightly regulated by neural activity (Demerens et al., 1996; Ishibashi et al., 2006), and coincides with the emergence of cognitive skills and abilities (Fornari et al.”
The early development of brain white matter: a review of imaging studies in fetuses, newborns and infants. (2014, background): “Astrocytes may act as an intermediary between myelination and electrical impulse activity, through the mediation of a cytokine leukemia inhibitory factor (Ishibashi et al., 2006).”
Remyelination in the CNS: from biology to therapy (2008, background): “However, increasingly well-developed protocols for myelination in co-cultures of oligodendrocytes and neurons have been develope”
Longitudinal Development of Human Brain Wiring Continues from Childhood into Adulthood (2011, background): “Myelination is promoted by electrical impulses across axons, suggesting that training and experience during development may influence myelination and thus inducing the observed diffusion parameter changes (Demerens et al., 1996; Ishibashi et al., 2006).”
The mystery and magic of glia: a perspective on their roles in health and disease. (2008, background): “Finally, simplified culture systems have revealed that myelinating oligodendrocytes receive a helping hand from astrocytes, particularly in the later stage of wrapping (Ishibashi et al., 2006; Sorensen et al., 2008; Watkins et al., 2008).”
White matter in learning, cognition and psychiatric disorders. (2008, positive): “No specificmechanismhasbeenproposed,butsomeastrocytes and NG2 cells have anatomical features to sense activity at the node of Ranvier and synapses [102], and astrocytes regulate myelination by releasing LIF [ 87 ].”
Oligodendrocytes: biology and pathology (2009, background): “Instead, it triggers the release of leukemia inhibitory factor (LIF) from astrocytes, which promotes myelination by mature oligodendrocytes [67].”