BACE1 is the major β-secretase for generation of Aβ peptides by neurons

By H. Cai, Yanshu Wang, D. McCarthy, H. Wen, D. Borchelt, Donald L. Price, Philip C. Wong. Nature Neuroscience, 2001

786 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. (2001, background): “Two other groups have, since the submission of this manuscript, reported viability in BACE knockout mice (15,16).”
Aβ Oligomers – a decade of discovery (2007, background): “…b-protein (Ab) production is mediated by the aspartyl protease, b-secretase (also called b-amyloid cleaving enzyme-1, BACE-1), and occurs immediately N-terminal to the Ab domain, simultaneously generating APPsb and the membranetethered C-terminal fragment, C99 (Vassar et al. 1999; Cai et al. 2001).”