Abnormal osmotic regulation in trpv4-/- mice

By W. Liedtke, J. Friedman. Proceedings of the National Academy of Sciences of the United States of America, 2003

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An introduction to TRP channels. (2006, neutral): “4 agonist (103, 105, 106) I COS PI(4,5)P2 TRPM8 38μM@17°C agonist (103) I COS PI(3,4,5)P3 TRPC6 20μM agonist (107) Ca HEK allicin TRPV1 51.”
Cellular and Molecular Mechanisms of Pain (2009, positive): “Analysis of TRPV4-deficient animals suggests a role in osmosensation as knockout animals display defects in blood pressure, water balance, and bladder voiding (Gevaert et al., 2007; Liedtke and Friedman, 2003).”
Trp ion channels and temperature sensation. (2006, background): “TREK1 is a member of the two-pore domain K+ channel expressed at high levels in peripheral DRG neurons, as well as in central hypothalamus.”
Mechanisms of sensory transduction in the skin (2007, background): “is consistent with a role in cutaneous touch, disrupting Trpv4 expression in mice has only modest effects on acute mechanosensory threshold”