RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

By P. von Hundelshausen, K. Weber, Yuqing Huo, A. Proudfoot, P. Nelson, Klaus Ley, C. Weber. Circulation, 2001

636 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/43519b9095185be8e41455345167e5c822194c89

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. Steffen Jung

In Immunology

1. A. Luster
2. Steffen Jung
3. A. Mócsai
4. Christian Weber
5. Klaus Ley
6. Ulrich H. von Andrian
7. Dan R. Littman
8. R. Alon

In Immunology and Allergy

1. A. Mócsai
2. Dan R. Littman
3. R. Alon
4. A. Luster
5. S. Nourshargh
6. P. Kubes
7. F. Tacke
8. L. Hammerich

Citations in the corpus

• Immune cell migration in inflammation: present and future therapeutic targets (2005, background): “Abrupt arrest has also been reported in vitro in neutrophils, monocytes and natural killer cell”
• Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “…in atherosclerotic plaque formation (Massberg et al., 2002; Huo et al., 2003) and platelet-derived CCL5 was shown to promote monocyte adhesion to the luminal surface of early atherosclerotic lesions in the inflamed arterial wall in mice (von Hundelshausen et al., 2001; Huo et al., 2003).”
• Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E (2003, background): “We have previously found that the CC chemokine CCL5 (regulated on activation, normal T cell expressed and secreted, RANTES) secreted by stimulated platelets is immobilized on microvascular or aortic endothelium and triggers monocyte arres”
• Getting to the site of inflammation: the leukocyte adhesion cascade updated (2007, background): “For example, platelets are known to deposit CC-chemokine ligand 5 (CCL5; previously known as RANTES), as well as other chemokines, such as CXC-chemokine ligand 4 (CXCL4) and CXCL5, onto the inflamed endothelium and thereby trigger the arrest of rolling monocyte”
• Chemokines and chemokine receptors in leukocyte trafficking. (2002, background): “RANTES, released by thrombinstimulated platelets, is present on the luminal surface of carotid arteries of apolipoprotein E-deficient mice with early atherosclerotic lesions, and this chemokine along with KC, but not MCP-1, can trigger monocyte arrest on atherosclerotic endothelium in an ex vivoperf”