Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability.

By J. Ferrell. Current Opinion in Cell Biology, 2002

1,172 citations recorded by the source corpus.

Subfields: Biophysics, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/43326fb9dffd09694d98f5161bcda357fcd5c556

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Citations in the corpus

Coordinating ERK/MAPK signalling through scaffolds and inhibitors (2005, background): “This can give rise to switch-like activation kinetics of ERK/MAPK and bistabilit”
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. (2007, background): “Positive feedback loops are often employed in such toggle-switch circuits where a transient signal can be converted into a long-lasting cellular response (Ferrell, 2002).”
Control of multistability (2014, background): “Nevertheless, it is generally accepted that two paradigmatic gene-regulatory networks in bacteria, the phage switch and the lac operon (at least when induced by non-metabolizable inducers), do show bistability [34,54,55].”
Nonlinear laser lithography for indefinitely large-area nanostructuring with femtosecond pulses (2013, background): “(3) The growth mechanism also has an imbedded negative feedback loop.”
Diversity in times of adversity: probabilistic strategies in microbial survival games. (2005, positive): “…noisy signals is imple - mented in cells by cascades , negative feedback , feed - forward architectures ( Mangan and Alon , 2003 ) , hyster - esis ( Ferrell , 2002 ) , orientational control of invertible DNA elements ( Wolf and Arkin , 2002 ) , and a variety of 1st , 2nd and 3rd order chemical…”
Soft inheritance: challenging the modern synthesis (2008, background): “tant role in the development of multicellular organisms (Ferrell, 2002).”
Cancer: a Systems Biology disease. (2006, background): “Feedback loops, in which a component of a pathway positively or negatively regulates the activity of upstream components of the pathway, can dramatically influence the output of a network (Bhalla and Iyengar, 1999; Ferrell, 1999, 2002; Kholodenko, 2000; Asthagiri and Lauffenburger, 2001).”
Control, exploitation and tolerance of intracellular noise (2002, neutral): “Feedback can also amplify the effects of noise by autocatalytic mechanism”
Stochasticity and Cell Fate (2008, background): “Systems of this kind are said to be bistable, that is, the system persists in one or another alternative state for prolonged periods of time [17].”
Cell-signalling dynamics in time and space (2006, background): “Complex dynamic properties have traditionally been associated with cascades of cycle”