CpG Stimulation of Primary Mouse B Cells Is Blocked by Inhibitory Oligodeoxyribonucleotides at a Site Proximal to NF-κB Activation

By P. Lenert, L. Stunz, Ae-Kyung Yi, Arthur M. Krieg, R. Ashman. 2001

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Receptor-Mediated Monitoring of Tissue Well-Being Via Detection of Soluble Heparan Sulfate by Toll-Like Receptor 41 (2002, methodology): “The following sequences were used for inhibition or stimulation of cells: CpG sequence (ODN1826) 5 -TCCATGACGTTCCT GACGTT-3 (24); non-CpG sequence (ODN1911) 5 -TCCAGGACTT TCCTCAGGTT-3 (24); and CpG inhibitory sequence 5 -TCCATG GCGGGCCTGGCGGG-3 (65).”
Therapeutic potential of Toll-like receptor 9 activation (2006, background): “Several types of suppressive ODN (S-class ODN) have been shown to block TLR9 signalling, but do not block activation of immune cells through TLR4, CD40 or the B-cell recepto”
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement (2005, background): “BWR4 could be blocked by s-ODN 2088 (Fig. 3 C). s-ODN 2088 was originally described as a specific inhibitor of TLR9 ( 21 ); however, it can also partially suppress the B cell response to the synthetic TLR7 ligand, R848, while having no effect on the response to LPS, anti-IgM F(ab � ) 2 , or TLR2 lig”