p63 is the molecular switch for initiation of an epithelial stratification program.

By M. Koster, Soeun Kim, A. Mills, F. DeMayo, D. Roop. Genes & Development, 2004

709 citations recorded by the source corpus.

Development of stratified epithelia, such as the epidermis, requires p63 expression. The p63 gene encodes isoforms that contain (TA) or lack (DeltaN) a transactivation domain. We demonstrate that TAp63 isoforms are the first to be expressed during embryogenesis and are required for initiation of epithelial stratification. In addition, TAp63 isoforms inhibit terminal differentiation, suggesting that TAp63 isoforms must be counterbalanced by DeltaNp63 isoforms to allow cells to respond to signals required for maturation of embryonic epidermis. Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c5a9c7b91e4be84744091f2d4c5e5311ebf48e3e

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Citations in the corpus

p63 is upstream of IKKα in epidermal development (2006, background): “Although p63 is involved in epithelial development (Mills et al., 1999; Yang et al., 1999), the relative contribution of these different isoforms to epidermal formation has been established at the molecular level only partially (Candi et al., 2006; Koster et al., 2004).”
A Functional Enhancer of Keratin14 Is a Direct Transcriptional Target of ΔNp63 (2007, background): “One aspect of p63 biology that remains unsettled is the conflicting data from different laboratories regarding the expression profile of TA and DNp63 isoforms, particularly during embryonic development (Koster et al., 2004; Laurikkala et al., 2006).”