Inflammation and colon cancer.

By J. Terzic, S. Grivennikov, Eliad Karin, M. Karin. Gastroenterology, 2010

1,989 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/415b57b8d9c14449f1bfb3091b9378a97eb1434c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. S. Shalapour
2. M. Karin
3. F. Greten

In Oncology

1. M. Karin
2. F. Greten
3. Y. Ben‐Neriah
4. S. Shalapour
5. Inder M. Verma
6. Shen Shen
7. Yifeng Xia
8. H. Hermeking

In Pathology and Forensic Medicine

1. S. Shalapour
2. M. Karin

Citations in the corpus

• Designing and developing a literature-derived, population-based dietary inflammatory index (2013, background): “Evidence also is accumulating on the role of chronic inflammation in cancer((2)), with colon cancer being the most well described((3)), as well as in diabetes, asthma, depression, metabolic syndrome and other diseases.”
• Inflammation meets cancer, with NF-κB as the matchmaker (2011, background): “Many inflammatory cytokines, including TNF, IL-6 and IL-23, produced by lamina propria macrophages and dendritic cells, as well as by tumor-associated macrophages, have been identified as the main drivers of CAC growt”
• Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “There is emerging information that chronic inflammation and host microbes may play key roles in not only IBD-related carcinogenesis but also in sporadic and other forms of CRC (285).”
• Immunity, inflammation, and cancer: an eternal fight between good and evil. (2015, positive): “and RNS release; sustain angiogenesis by releasing VEGF, MMP-9, or prokineticin 2 (Bv8); and enhance neoplastic cell invasiveness through soluble mediators (e.g., oncostatin M [OSM] and HGF) (56, 73, 74).”
• NF-κB, an Active Player in Human Cancers (2014, positive): “In patients with inflammatory bowel disease (IBD), for example, immune cells infiltrating the gastrointestinal mucosa secrete pro-tumorigenic cytokines such as TNF-α , IL-1, and IL-17 to elevate NF-κ B activity, and increasing the risk of colon cancer (13).”
• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “For example, inflammatory bowel disease or colitis are important risk factors for CRC (8).”
• A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS) (2013, background): “from cigarette smoking, infection or hypertension, and evidence is accumulating on the role of chronic inflammation in cancer((1)), with colon cancer being the most well described((2)).”
• Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers (2011, background): “Other sporadic CRCs, which are not associated with clinically detectable inflammatory bowel disease, also display robust inflammatory infiltration and increased expression of proinflammatory cytokines (Terzic et al., 2010).”