Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model

By F. Giorgio, M. Carrasco, M. Siao, T. Maniatis, K. Eggan. Nature Neuroscience, 2007

813 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/4147a45a52048ff1021ef68247aa67278adda47a

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Citations in the corpus

A fresh look at iPS cells. (2009, background): “For example, motor neurons alone derived from ALS patient-specific iPS cells may not be able to reconstitute full disease pathogenesis as they may need to interact with glial cells (Di Giorgio et al., 2007).”
Reactive Astrocytes: Production, Function, and Therapeutic Potential. (2017, background): “Astrocytes cultured from the Sod1G93A mutant mouse release a factor that can kill motor neurons (Di Giorgio et al., 2007; Nagai et al., 2007; Lobsiger et al., 2007).”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “…the idea of probing the effect of different cell types on the development of a disease has been demonstrated by different laboratories studying mouse and human models of ALS, another condition characterized by the loss of motor neurons (Di Giorgio et al. 2007, 2008; Marchetto et al. 2008).”
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders (2011, background): “According to an emerging hypothesis of ALS that is based on studies in SOD1 mutant mice, the toxicity that is derived from non-neuronal neighbouring cells, particularly microglia and astrocytes, contributes to disease progression and motor neuron degeneratio”
The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, positive): “Neurovascular Unit The current model of ALS disease suggests that toxicity derived from microglia and astrocytes contributes to disease progression and motor neuron degeneration (Boillée et al., 2006a, 2006b; Beers et al., 2006; Di Giorgio et al., 2007; Nagai et al., 2007).”
Astrocytes: biology and pathology (2009, background): “Recent findings show that expression of ALS mutant SOD in astrocytes (but not other cell types) leads to production by astrocytes of soluble molecules that are selectively toxic to motor neurons but not to spinal cord interneurons [53, 158], but the nature of the toxic molecules and the mechanisms l”