MYB function in normal and cancer cells

By R. Ramsay, T. Gonda. Nature Reviews. Cancer, 2008

621 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/413d1d09d453b796eb562380288634bb66bcbb16

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Chuan He
2. Hailing Shi
3. H. Horlings
4. Jianhua Yang

In Molecular Biology

1. Chuan He
2. Hailing Shi
3. Jianjun Chen
4. Huilin Huang
5. Hengyou Weng
6. R. Su
7. Zhike Lu
8. B. Zhao

Citations in the corpus

• Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck (2009, background): “MYB plays an important role in the control of cell proliferation, apoptosis, and differentiation, is highly expressed in immature, proliferating cells, and is down-regulated as cells become more differentiated (10, 11).”
• Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival (2011, result): “We wanted to find out whether other genes, known to be associated with (or downstream of) c-MYB overexpression (12), also show similar association in the c-MYB tumor group.”
• Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, background): “…to establish a robust and consistentmodel of immune cell ontogeny from the early embryonic stage right through to the steady-state adult. c-Myb Dependence c-Myb is a transcription factor required for the expansion and differentiation of all hematopoietic cell lineages (Ramsay and Gonda, 2008).”
• Polycomb group proteins: navigators of lineage pathways led astray in cancer (2009, neutral): “Some specific examples include the oncogenes MYB”
• METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification (2017, background): “MYB and MYC both are master regulators of self-renewal and differentiation of normal HSPCs and AML cells (Ramsay andGonda, 2008;Wall et al., 2008) and are essential for AML initiation andmaintenance (Delgado and León, 2010; Ramsay and Gonda, 2008).”