Cancer/testis antigens, gametogenesis and cancer

By A. Simpson, O. Caballero, A. Jungbluth, Yao-Tseng Chen, Lloyd J. Old. Nature Reviews. Cancer, 2005

1,613 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/411e4e9a95f34925ad462929409a803cad29e8b3

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Citations in the corpus

Targets and dynamics of promoter DNA methylation during early mouse development (2010, positive): “Second, many of these genes are overexpressed in cancer, which suggests that their ectopic reactivation negatively impacts somatic cellular integrit”
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells (2008, background): “T he molecular identification of tumor-associated Ags has provided many potential targets for the development of therapeutic cancer vaccines (1).”
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. (2013, background): “MAGE-A3 has been prioritized by the National Cancer Institute as the top-rated cancertestis antigen immunotherapy target because of its frequent expression in many types of cancer and lack of expression on adult cells that express HLA class I antigens.(15,16) Heretofore, infusions with engineered T ”
The Blood-Testis Barrier and Its Implications for Male Contraception (2012, background): “, 1988, 1990), as well as cancer/testis antigens (Kalejs and Erenpreisa, 2005; Simpson et al., 2005; Wong et al., 2008a; Caballero and Chen, 2009), which are oncogenes transiently expressed in these more primitive germ cells.”
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome (2007, methodology): “The set of autosomal genes with germline-specific expression was generated from published literatur”
Stability and flexibility of epigenetic gene regulation in mammalian development (2007, background): “Silencing by both histone modifications and DNA methylation in somatic tissues seems to be typical of this group of genes and of those that encode cancer–testis antigens, which are expressed during spermatogenesi”
Adoptive immunotherapy for cancer: harnessing the T cell response (2012, neutral): “Tümörtestis antijenlerini yaygın bir şekilde eksprese eden tümörler şunlardır: melanom, akciğer karsinomu, baş boyun, özefagus ve mesane kanserleri (37).”
Molecular and genetic properties of tumors associated with local immune cytolytic activity (2015, positive): “Ectopic expression is likely due to disturbances in genomic methylation and reactivation of stem-like expression programs that may contribute to tumorigenicity (Simpson et al., 2005).”