Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

By Michael Weber, Ines Hellmann, Michael B. Stadler, L. Ramos, Svante Pääbo, M. Rebhan, Dirk Schübeler. Nature Genetics, 2007

2,239 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/56706b53529ed9ac3e0fae74d6d45473f37d39b9

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Citations in the corpus

CpG methylation of half-CRE sequences creates C/EBPα binding sites that activate some tissue-specific genes (2010, background): “Genomic analyses have identified low CpG promoters that are both methylated and transcriptionally active (8, 12), but the mechanism underlying the activation of methylated promoters remains unclear.”
CpG islands and the regulation of transcription. (2011, neutral): “CGIs in the germline are almost invariably nonmethylated, but a small proportion acquire methylation in somatic tissues (Schilling and Rehli 2007; Shen et al. 2007; Weber et al. 2007).”
CpG islands – ‘A rough guide’ (2009, background): “Recently, DNA ‘‘methylome” characterisation has been the basis for an increasing number of investigations due to significant advances in analytical technologies [1,2,10,29,60].”
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis (2008, background): “) and the first high-resolution DNA methylation profile of human promoter”
Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores (2009, background): “It has previously been reported that the degree of differences in DNAm of promoters in somatic cells is relatively low in conventionally defined CpG islands and higher at promoters with intermediate CpG densit”
Ensembl regulation resources (2016, background): “Complex interactions with polymerases, transcription factors (TF) and enzymes that modify histones and DNA (1–3) as well as its spatial structure (4, 5) largely determine the functional activity of the cell’s chromatin, in particular the controlled transcription of genes (6), which in turn controls…”
The Ensembl Regulatory Build (2015, background): “Gene expression is also highly tied to transmissible epigenetic marks [6-8].”
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation (2009, background): “Epigenetic Signals on Critical Transcriptional Regulatory Elements H3K4 methylation has been detected at silent loci in ESCs and differentiated cells (Barski et al., 2007; Bernstein et al., 2006; Guenther et al., 2007; Meissner et al., 2008; Mikkelsen et al., 2007; Roh et al., 2006; Wang et al., 200”
Neuronal activity modifies DNA methylation landscape in the adult brain (2011, background): “15b ), suggesting that the role of low-density CpGs in regulating gene expression may have been previously underappreciate”