Transgenic plants as factories for biopharmaceuticals

By G. Giddings, G. Allison, D. Brooks, A. Carter. Nature Biotechnology, 2000

595 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/41092f8b5c4844352704ab699786bfea3b0dadf6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. H. Daniell
2. R. Twyman
3. J. Grevich
4. P. Christou
5. E. Stoger
6. R. Fischer
7. Oliver Fiehn
8. Olivier Voinnet

In Molecular Biology

1. H. Daniell
2. R. Twyman
3. Olivier Voinnet
4. J. Grevich
5. David C. Baulcombe
6. P. Christou
7. E. Stoger
8. R. Fischer

Citations in the corpus

• An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus. (2003, background): “The use of plants as expression systems for valuable recombinant proteins often involves integration of a transgene into the plant genome (Giddings et al., 2000).”
• Chloroplast Genetic Engineering: Recent Advances and Future Perspectives (2005, methodology): “Several plant-based production platforms have been developed based on protein expression from the nuclear genome and viral vectors in leaf, seed, tuber, and tissue-cultured cells ( Ma, 2000 ; Giddings et al.”
• Combining Genomics, Metabolome Analysis, and Biochemical Modelling to Understand Metabolic Networks (2001, background): “enhancing the nutritional value of foods) or into pathways needed for the production of pharmaceuticals in plants [30].”
• Metabolomics – the link between genotypes and phenotypes (2004, background): “) or into pathways needed for the production of pharmaceuticals in plants (Giddings et al., 2000).”
• A comparison between crop domestication, classical plant breeding, and genetic engineering (2002, background): “Such approaches have pharmaceutical (Giddings et al., 2000), or industrial been applied to a limited number of crops, including products (e.”
• Chloroplast expression of His-tagged GUS-fusions: a general strategy to overproduce and purify foreign proteins using transplastomic plants as bioreactors (2004, background): “Transgenic plants make an attractive system for largescale production of proteins due to low production costs and easily scaleable capacity (Giddings et al. 2000; Goddijn and Pen 1995; Hood and Jilka 1999).”
• Validation of Candidate Reference Genes for the Accurate Normalization of Real-Time Quantitative RT-PCR Data in Rice During Seed Development (2010, background): “A comprehensive expression profiling of genes involved in rice seed development will provide us with a great deal of information for developing appropriate approaches to increase both yield and quality of rice as well as to maximize the synthesis and accumulation of foreign proteins by regulating th”
• Practical considerations for pharmaceutical antibody production in different crop systems (2002, background): “Recombinant antibodies have been produced in various different crop systems, which have been excellently reviewed elsewhere (Daniell et al. 2001; Fischer and Emans 2000; Van der Logt et al. 1998; Giddings et al. 2000).”
• Genetic, Molecular, and Genomic Approaches to Improve the Value of Plant Foods and Feeds (2002, background): “Many aspects of the nutritive value of plants and how to improve it have already been discussed (for examples see Abelson and Hines, 1999; Agarwal and Rao, 2000; Baucher et al., 1998; Brink and Beynen, 1992; Dillard and German, 2000; Dixon and Steele, 1999; Dunwell, 1999; Dunwell, 2000; Galili, 1995”