Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene

By Jiying Sun, H. Hoshino, K. Takaku, O. Nakajima, A. Muto, Hiroshi Suzuki, S. Tashiro, Satoru Takahashi, S. Shibahara, J. Alam and 3 more. EMBO Journal, 2002

647 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/40e312ee62ee7a82256f6ab1279fbcdaf0a88371

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. Q. Ma

In Molecular Biology

1. Rui Wang
2. K. Frese
3. Suresh Niture
4. Anil K. Jaiswal
5. Lingyun Wu
6. James W. Kaspar
7. D. Tuveson
8. Q. Ma

Citations in the corpus

• Nrf2:INrf2(Keap1) Signaling in Oxidative Stress (2009, background): “tion factor 1) is a transcription repressor [62] that is ubiquitously expressed in tissues [63,64] and distantly related to Nrf2 [8].”
• Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis (2011, methodology): “DNA was purified with a QIAquick spin kit (Qiagen) and Q-PCR was performed in triplicate with a Power SYBR Master Mix (Applied Biosystems) on an Applied Biosystems 7900HT with the following primer”
• Stress-Activated Cap’n’collar Transcription Factors in Aging and Human Disease (2010, neutral): “development and reproduction in mice (18).”
• Role of nrf2 in oxidative stress and toxicity. (2013, background): “Induction requires a common DNA sequence called antioxidant response element (ARE) that resembles the NFE2-binding motif (9).”
• Mechanisms of cell protection by heme oxygenase-1. (2010, background): “by the observation that Bach1-deficient (Bach1−/−) cells express constitutive high levels of Hmox1 mRNA, an effect that is not ablated in cells also lacking Nrf-2 (Bach1−/−Nrf2−/−) (32).”
• Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications (2005, background): “Bach1, a member of basic leucine-zipper factors, is a heme-regulated transcriptional repressor for the HO-1 gene (Kitamuro et al., 2003; Sun et al., 2002; Kitamuro et al., 2003).”
• Oxidative stress response and Nrf2 signaling in aging. (2015, neutral): “Later the same group showed that Bach1 abrogated Nrf2/EpRE-mediated HO-1 induction [360].”