Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.

By J. Valladeau, Odile Ravel, C. Dezutter‐Dambuyant, K. Moore, M. Kleijmeer, Yong‐jun Liu, Valérie Duvert-Frances, C. Vincent, D. Schmitt, J. Davoust and 3 more. Immunity, 2000

1,045 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/402aecd8965c2c3ab407567bc4e2b3385530b6c4

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Citations in the corpus

BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction (2001, background): “Langerin is specifically expressed by Langerhans cells, whereas the MMR, CD23, and DEC-205 are not specifically expressed by DCs in general or by a particular DC subset.”
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens (2004, background): “Finally, Langerhans’ cells and dermal DCs are most easily distinguished from each other by their respective expression of high versus intermediate levels of CD205, and further by the high intracellular expression of langerin in Langerhans’ cells (96).”
Dendritic cells as therapeutic vaccines against cancer (2005, background): “: Langerhans cells express langerin, which is crucial for the formation of Birbeck granule”
Dendritic cells: specialized and regulated antigen processing machines. (2001, background): “BGs are enriched in a lectin, langerinSignals Leading to Dendritic Cell Maturation (CD207), whose expression even in fibroblasts can in-DC maturation is typically triggered by products of miduce granule formation (Valladeau et al., 2000).”
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells (2008, background): “Immunization experiments in which mice were injected with human LC-like cells that had been generated in vitro from CD34 + haematopoietic progenitor cells led to the identification of langerin ( CD207 ), a lectin receptor that is expressed at high levels by LCs in humans and mic”
Steady-state and inflammatory dendritic-cell development (2007, background): “So, the epidermal LCs, even after arrival in the lymph node, are readily distinguished from the dermally derived DCs by high levels of expression of langeri”