Stimulation of Medial Prefrontal Cortex Decreases the Responsiveness of Central Amygdala Output Neurons

By Gregory J. Quirk, E. Likhtik, J. Guillaume Pelletier, Denis Paré. Journal of Neuroscience, 2003

958 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/40118a2e233eb8b65c08a08bee546bdfd20faaba

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Citations in the corpus

The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007, background): “…involved in emotion-ality, such as the amygdala, dorsal raphe and hypothalamus (Arnsten and Goldman-Rakic [428]; Sesack and Pickel [429]; Rempel-Clower and Barbas [430]; Haj´os et al. [431]; Quirk and Gehlert [432]; Quirk et al. [433]; Milad et al. [434]; Likhtik et al. [379]; Amat et al. [388]).”
Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder (2011, background): “The OFC has a crucial role in the modulation of fear via the amygdala (Quirk et al., 2003; Rosenkranz and Grace, 2002).”
Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. (2007, background): “…with the top-down control of the amygdala by he vmPFC, if as previously suggested, the vmPFC dampens the utput of the amygdala by activating the intercalated clusters of -aminobutyric acid [GABA]ergic neurons (ITC) within the amygala (Berretta et al. 2005; Quirk et al. 2003; Rosenkranz et al. 003).”
Putting Feelings Into Words (2007, positive): “vation is particularly interesting given that MPFC has dense anatomical projections to the amygdala and has been implicated in extinction-related control of amygdala activity in both rodents and humans (Phelps et al., 2004; Quirk et al., 2003; see also Heinz et al., 2005).”
Facial expressions and complex IAPS pictures: Common and differential networks (2006, background): “, 2003), extinguished fear (Milad and Quirk, 2002; Milad et al., 2004; Quirk et al., 2003), and cognitive-emotion interactions (Liberzon et al.”
The neural bases of emotion regulation: reappraisal and suppression of negative emotion. (2008, positive): “In particular, lesion studies have found that the medial PFC plays an essential role in inhibitory control of amygdala output (50).”
Emotion Regulation and the Anxiety Disorders: An Integrative Review (2010, background): “Electrical stimulation of the mPFC in rodents following a fear-conditioning paradigm reduces neural responding in the lateral nucleus (Rosenkranz et al., 2003) and central nucleus (Quirk et al., 2003) of the amygdala.”
Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. (2006, methodology): “These projections are excitatory (Quirk et al. 2003), causing CeM output neurons to trigger midbrain and hypothalamic structures responsible”
Neurobiology of the incubation of drug craving (2011, neutral): “However, while there are excitatory projections from the ventral mPFC to CeA [99], electrophysiological studies show that ventral mPFC stimulation decreases CeA neuronal activity [100].”
Brain On Stress: Vulnerability and Plasticity of the Prefrontal Cortex Over the Life Course (2013, neutral): “…impairment of hippocampal LTP and spatial memory (Kim et al., 2005) and stimulation of basolateral amygdala enhances dentate gyrus field potentials (Ikegaya et al., 1996), while stimulation of medial prefrontal cortex decreases responsiveness of central amygdala output neurons (Quirk et al., 2003).”
Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear (2010, neutral): “Moreover, infralimbic stimuli block the excitation of CEm neurons by BL inputs (388), an effect thought to depend on the activation of ITCm cells by infralimbic stimuli.”
Predictors of amygdala activation during the processing of emotional stimuli: a meta-analysis of 385 PET and fMRI studies. (2008, background): “These medial and dorsolateral frontal areas produce an inhibitory effect on amygdala function, which has been observed in rodents (Rosenkranz et al., 2003; Quirk et al., 2003; Sotres-Bayon et al., 2004) and humans (Hariri et al., 2003; Pezawas et al., 2005).”