Detection of Ectopic B‐cell Follicles with Germinal Centers in the Meninges of Patients with Secondary Progressive Multiple Sclerosis

By B. Serafini, B. Rosicarelli, R. Magliozzi, E. Stigliano, F. Aloisi. Brain Pathology, 2004

1,196 citations recorded by the source corpus.

Subfields: Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/3f9a57bf25698d541c27251e64c72e4817ef2e88

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Hans Lassmann
2. R. Ransohoff
3. Melissa A Brown
4. F. Aloisi
5. Berislav Zlokovic
6. J. Goverman

In Pathology and Forensic Medicine

1. Hans Lassmann
2. R. Ransohoff
3. Wolfgang Brück
4. C. Lucchinetti
5. Melissa A Brown
6. F. Aloisi

Citations in the corpus

• Cortical demyelination and diffuse white matter injury in multiple sclerosis. (2005, background): “Recently it was shown that in SPMS the inflammatory reaction leads to the formation of lymphatic like structures within the meninges and the perivascular spaces (Serafini et al., 2004).”
• CNS immune privilege: hiding in plain sight (2006, background): “Within the CNS, such features have been detected within the meninges but not in the CNS parenchyma of patients with secondary progressive MS (54).”
• The Immunopathology of Multiple Sclerosis: An Overview (2007, background): “In patients with progressive MS, focal areas of inflammation can be found in the meninges, which closely reflect the structural features of B cell follicles (82).”
• Multiple Sclerosis Pathology. (2018, background): “In the meninges, inflammatory cells form large aggregates, which show features of tertiary lymphatic tissue (Serafini et al. 2004; Franciotta et al. 2008; Pikor et al. 2016).”
• Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. (2011, background): “In agreement with our description of the presence of B cell follicle-like tissues in the post-mortem multiple sclerosis brain (Serafini et al., 2004, 2007; Magliozzi et al., 2007, 2010), analysis of patient CSF has identified the recapitulation of all features of B cell development, normally…”
• Innate immunity in the central nervous system. (2012, positive): “Because neutrophils also promote B cell survival and proliferation (120), innate neutrophils and mast cells might contribute to the B cell follicle–like structures that are found at autopsy in the meninges of MS tissues (134, 135).”
• Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis (2019, background): “Meningeal inflammation is present in the form of diffuse infiltrates or of inflammatory aggregates containing densely packed T-cells, B-cells, and Plasma cells, which in most severe forms resemble tertiary lymphatic follicles (64).”
• Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. (2007, background): “This study includes three SPMS (MS79, MS80 and MS85) and two PPMS (MS83 and MSG1) cases that were already examined in Serafini et al. (2004).”