Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response.

By J. Liuzzi, Louis A. Lichten, S. Rivera, R. Blanchard, T. Aydemir, M. Knutson, T. Ganz, R. Cousins. Proceedings of the National Academy of Sciences of the United States of America, 2005

595 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/3f46be63923bf97bd8474e68f36cdc599fc21296

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Citations in the corpus

The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. (2015, background): “Both isoforms are localized to the plasma membrane and import zinc (127, 161, 251).”
Effects of prenatal infection on brain development and behavior: a review of findings from animal models. (2010, unknown): “IL-6 mediated induction of zinc transporters may also play a role in the hypozincaemia associated with LPS exposure (Liuzzi et al., 2005).”
Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling (2017, background): “Finally, hypozincemia can be caused by factors unrelated to zinc status, such as ongoing acute phase response (APR) or hypoalbuminemia (Livingstone 2015).”
IL-6 in inflammation, immunity, and disease. (2014, background): “IL-6 also enhances zinc importer ZIP14 expression on hepatocytes and so induces hypozincemia seen in inflammation (Liuzzi et al. 2005).”