Innate immune sensing and signaling of cytosolic nucleic acids.

By Jiaxi Wu, Zhijian J. Chen. Annual Review of Immunology, 2014

1,121 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3f221e774d21a8bb63ff4e21dafa9243c58e6a88

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In Immunology

Citations in the corpus

Control of adaptive immunity by the innate immune system (2015, background): “When CD22 is engaged by its sialic acid ligand, it activates the lipid phosphatase SHIP, which converts phosphatidylinositol-(3,4,5)trisphosphate (generated by PI(3)K) into phosphatidylinositol-(3,4)-bisphosphate and thus inhibits downstream steps in the PI(3)K signaling pathway96.”
Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017, background): “Microglial PRRs include Toll-like receptors (TLRs), such as TLR4 and TLR1/2, and their coreceptors, such as CD14 (16, 17); NOD-like receptors (NLRs), such as the NLRP3 inflammasome (17); receptors for nucleic acids (18); and C-type lectin receptors (CLRs), such as CLEC7A (19).”
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases (2015, background): “RIG-I and its homolog MDA5 detect viral RNA in the cytoplasm and induce IFNs through a similar pathway, except that the essential adaptor protein functioning downstream of RIG-I and its homolog MDA5 is the mitochondrial membrane protein MAVS, not STING (2, 19).”
Phagocytosis: An Immunobiologic Process. (2016, background): “Returning to digestion and its significance, lysosomal DNase II is important for digestion; escape of DNA into the cytosol stimulates cGAS-STING-mediated induction of pro-inflammatory cytokines such as type I interferon and tumor necrosis factor (TNF) (Wu and Chen, 2014).”
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status (2020, background): “Usually, Toll-like receptor (TLR) 3, TLR7, TLR8, and TLR9 sense viral RNA and DNA in the endosome [60, 61].”
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “…the cGAS–STI NG pathway and its pivotal roles in eliciting effective immunity against various microbial pathogens have been extensively reviewed elsewhere (Xiao and Fitzgerald, 2013; Cai et al., 2014; Wu and Chen, 2014; Chen et al., 2016b; Ma and Damania, 2016; Tao et al., 2016; Kato et al., 2017).”
STING-dependent Cytosolic DNA Sensing Promotes Radiation-induced Type I interferon-dependent Antitumor Immunity in Immunogenic Tumors (2014, background): “Various nucleic acid-sensing pathways from different subcellular compartments have been reported to play a critical role in inducing type I IFNs in response to pathogen infection and tissue injury (Desmet and Ishii, 2012; Wu and Chen, 2014).”