Control of adaptive immunity by the innate immune system

By A. Iwasaki, R. Medzhitov. Nature Immunology, 2015

1,936 citations recorded by the source corpus.

Microbial infections are recognized by the innate immune system both to elicit immediate defense and to generate long-lasting adaptive immunity. To detect and respond to vastly different groups of pathogens, the innate immune system uses several recognition systems that rely on sensing common structural and functional features associated with different classes of microorganisms. These recognition systems determine microbial location, viability, replication and pathogenicity. Detection of these features by recognition pathways of the innate immune system is translated into different classes of effector responses though specialized populations of dendritic cells. Multiple mechanisms for the induction of immune responses are variations on a common design principle wherein the cells that sense infections produce one set of cytokines to induce lymphocytes to produce another set of cytokines, which in turn activate effector responses. Here we discuss these emerging principles of innate control of adaptive immunity.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/4eb4e6e3b87195c5a4c045d1090f765f4746d8f9

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In Immunology

1. Victor J. Torres
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Citations in the corpus

• The Sleep-Immune Crosstalk in Health and Disease (2019, background): “, intracellular (viral and bacterial) infection: type I IFNs/IL-12, Th1, IgG1, IgG3; helminth infection: IL-4, Th2, IgG4, IgE; fungal infection: IL-23, Th17], hallmarking the close interplay between the innate and adaptive arm of the immune system (266, 368, 566).”
• Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, neutral): “The specific cytokine profile is critical for eradicating pathogens and tumors (Dranoff, 2004; Iwasaki and Medzhitov, 2015).”
• ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA (2015, background): “The innate immune system provides a rapid initial reaction to invading pathogens and also stimulates the adaptive immune system (Iwasaki and Medzhitov, 2015).”
• Phagocytosis: An Immunobiologic Process. (2016, background): “Iwasaki and Medzhitov have summarized in detail how specialized DC populations sense the nature of microbial intracellular infection to activate appropriate effector responses (Iwasaki and Medzhitov, 2015).”
• Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery. (2017, neutral): “A critical role of the innate immune system is to scan foreign material and relay critical information to the adaptive immune system to modulate the strength and quality of protective immunity.(19,60,61) In general, this occurs through activation of PRRs.”
• Staphylococcus aureus Impairs the Function of and Kills Human Dendritic Cells via the LukAB Toxin (2019, background): “Bridging innate immunity and adaptive immunity, DCs fulfill an indispensable role in the development of durable immune protection by producing proinflammatory cytokines and presenting microbial antigens to lymphocytes (12).”