The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status

By Yanrong Guo, Qing Cao, Z. Hong, Yuanyang Tan, Shou-Deng Chen, Hongjun Jin, K. Tan, D. Wang, Yan Yan. Military Medical Research, 2020

4,236 citations recorded by the source corpus.

An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/c1931312e5485988ef28bd565a0d1a1b0cae80b1

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Citations in the corpus

The psychology of coronavirus fear: Are healthcare professionals suffering from corona-phobia? (2020, background): “specifics of quarantine and how to promote adherence to infection control measures [1, 3].”
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The COVID-19 Cytokine Storm; What We Know So Far (2020, background): “Although the first data available about COVID-19 indicates possible animal-to-human transmission via wild animals in Huanan seafood Market in Wuhan (5, 6), epidemiological data and studies, after that, have increasingly demonstrated that the virus transmits human-tohuman, through droplets or direct ”
Knowledge, Perceptions, and Attitude of Egyptians Towards the Novel Coronavirus Disease (COVID-19) (2020, background): “The elderly and patients with comorbidities are more likely to be infected and are additionally more prone to serious complications, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm [5].”
COVID-19: Transmission, prevention, and potential therapeutic opportunities (2020, positive): “The WHO has stated that education, isolation, prevention, controlling the transmission, and treatment of infected persons are the critical steps in controlling contagious diseases like COVID-19 [52].”
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease (2020, neutral): “The first cases of infection by this virus were reported in a shellfish market in south Wuhan in December 2019 [3], and it proved impossible to rule out human-human transmission.”
The impact of physical activity on psychological health during Covid-19 pandemic in Italy (2020, background): “The transmission of COVID-19 occurs mainly through droplet and close contact [5].”
Predicting COVID-19 Incidence Through Analysis of Google Trends Data in Iran: Data Mining and Deep Learning Pilot Study (2020, background): “COVID-19: coronavirus disease LSTM: long short-term memory RMSE: root mean square error SEIR: Susceptible Exposed to Infectious Recovered WHO: World Health Organization Edited by G Eysenbach; submitted 21.03.20; peer-reviewed by S Facente, G Fagherazzi; comments to author 25.03.20; revised version r”
COVID-19 and diabetes: Knowledge in progress (2020, positive): “Findings from virus genome sequencing analysis have pointed out that SARS-CoV-2 and bat coronavirus (bat CoV) might share the same ancestor, although bats are not for sale in this seafood market [11].”
COVID‐19 and Older Adults: What We Know (2020, background): “Keywords: coronavirus; COVID-19; mortality; older adults; SARS-CoV-2 Clusters of pneumonia cases occurring in the city of Wuhan in December 2019 led to the eventual identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).(1,2) Through an epidemiological investigation, the Chin”