The many ways of Wnt in cancer.

By Paul Polakis. Current Opinion in Genetics and Development, 2007

927 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3e888865b4fa53723396f9227340d0a211a8bad3

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In Molecular Biology

1. W. Birchmeier
2. D. Nguyen
3. J. Massagué
4. M. Resh
5. Paul Polakis
6. X. Zhang
7. Eléonore Beurel
8. Alexandra Klaus

Citations in the corpus

• Wnt signaling in cancer. (2012, background): “Regulation of b-catenin also fails when b-catenin itself contains mutations that prevent it from being marked for destruction by the kinases (Polakis 2007).”
• Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling (2012, background): “Multiple Wnttriggered pathways coordinately regulate key developmental processes as well as adult tissue homeostasis and repair, and are dysregulated in diverse diseases including cancer, malformation syndromes, osteoporosis, diabetic retinopathy, and pulmonary fibrosis (1-5).”
• Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases (2014, background): “The variable role of GSK3 in different cancers also may be related to the role of β-catenin, which can be activated by GSK3 inhibitors (Polakis, 2007; Anastas and Moon, 2012).”
• Emerging roles of Wnts in the adult nervous system (2010, background): “A deregulation of such mechanisms, either at a genetic or an epigenetic level, leading to excessive Wnt–β-catenin signalling has been linked to oncogenesis in many different tissue”
• Targeting Protein Lipidation in Disease (2012, background): “Dysregulation of Wnt signaling pathways induces oncogenesis [49].”
• Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer (2009, background): “Less frequently, loss of extracellular inhibitors that normally suppress Wnt protein function may give rise to Wnt ligand–dependent tumor”
• Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling (2009, neutral): “Inappropriate activation of the Wnt pathway has been observed in manycancers 2,3 .”
• Wnt signalling and its impact on development and cancer (2008, background): “More recent and far more extensive mutational surveys indicate that the frequency in sporadic colorectal cancers is actually closer to 1% (reviewed in Ref”
• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, background): “Mutations that constitutively activate the WNT pathway are frequently involved in colorectal cancer initiation (Clevers, 2006; Moon et al., 2004; Morin et al., 1997; Polakis, 2007).”
• TCF/LEFs and Wnt signaling in the nucleus. (2012, background): “It is the essential function of Wnt signaling in stem cell self-renewal and cell proliferation that links this pathway to problems of aging and disease such as cancer and diabetes (Polakis 2007; Laudes 2011).”
• The many faces and functions of β‐catenin (2012, neutral): “Such mutations result in aberrantly activated b -catenin signalling and contribute to the development of various types of cancer (Polakis, 2007; Lucero et al, 2010).”