Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

By Shih-Min A. Huang, Y. Mishina, Shanming Liu, Atwood K Cheung, F. Stegmeier, G. Michaud, O. Charlat, E. Wiellette, Yue Zhang, S. Wiessner and 26 more. Nature, 2009

2,035 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/927417923ef87a2a48eed9321ab8d4a9fd7330ad

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In Molecular Biology

1. D. Sinclair
2. Yanqin Zuo
3. G. Schulte
4. Peter G. Schultz
5. J. Petersen
6. L. Yao
7. Yitian Wang
8. L. Ye

Citations in the corpus

• Wnt/beta-catenin pathway: modulating anticancer immune response (2017, background): “Axin is a concentration-limiting component of the β-catenin destruction complex, and its stability is regulated by tankyrase, the key regulator enzyme that is responsible for poly(ADP-ribosyl)ation (PARsylation) of axin and induces its proteasomal degradation [68, 69].”
• Wnt/β-catenin signaling in cancers and targeted therapies (2021, background): “This SMI stabilized Axin to increase β-catenin degradation by suppressing Tnks1/2.(171) It has been investigated that beside from CRC, XAV939 can constrain certain cancers by inhibiting the Wnt/β-catenin signaling.”
• INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3 (2014, positive): “TOPflash assays reporting the transcriptional activity of β-catenin have been of great importance in the understanding of the biological importance of the WNT/β-catenin pathway and have proven partially successful in drug screening as well (Huang et al., 2009).”
• Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 (2013, methodology): “In this assay, Wnt-secreting cells, a stable L-cell line overexpressing Wnt3A, were cocultured with the Wnt reporter cells, a TM3 cell line harboring a luciferase reporter gene (19) driven by Wnt-responsive promoter elements.”
• Therapeutic potential of NAD-boosting molecules: the in vivo evidence (2018, positive): “Additionally, PARP5a and 5b, also known as tankyrases, are involved in mitosis and Wnt signaling (Chang et al., 2005; Chi and Lodish, 2000; Huang et al., 2009).”