Persistent postsurgical pain: risk factors and prevention.

By Henrik Kehlet, T. S. Jensen, Clifford J. Woolf. The Lancet, 2006

3,855 citations recorded by the source corpus.

Subfields: Anesthesiology and Pain Medicine, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/3e6d2beb85f06eb6c8c39c2f4ce9ae1f27bf3186

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Anesthesiology and Pain Medicine

1. Clifford J. Woolf
2. T. Gan
3. R. Ji
4. Lee Simon
5. Henrik Kehlet

In Physiology

1. Clifford J. Woolf
2. R. Ji
3. M. Suter
4. J. Scholz
5. J. Mogil
6. T. Gan
7. Henrik Kehlet
8. Lee Simon

In Surgery

1. Clifford J. Woolf
2. T. Gan
3. R. Ji
4. Lee Simon
5. Henrik Kehlet

Citations in the corpus

• p38 MAPK, microglial signaling, and neuropathic pain (2007, background): “Peripheral nerve injury also induces marked phenotypic changes in DRG neurons [1,2].”
• Animal models of pain: progress and challenges (2009, background): “However, the number of sufferers of causalgia is dwarfed by the numbers of sufferers of other neuropathic disorders, including painful diabetic neuropathy, post-herpetic neuralgia, persistent post-surgical pain, trigeminal neuralgia, cancer-associated neuropathic pain and spinal cord injury-related ”
• Severity of Acute Pain After Childbirth, but not Type of Delivery, Predicts Persistent Pain and Postpartum Depression (2008, background): “Poorly controlled acute post-procedural pain may result in harmful physiologic and psychological consequences, including prolonged hospitalization and delayed return to normal activities [25], and is associated with an increased risk of chronic pain [13,20].”
• Poorly controlled postoperative pain: prevalence, consequences, and prevention (2017, background): “Fluctuations in reported incidence of chronic postsurgical pain are likely associated in part with the lack of a standardized definition of this complication, although it is frequently defined as enduring pain that has no other evident causes and lasts at least 2 months after surgery, ie, past the e”
• Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms (2012, neutral): “Most patients do not develop neuropathic pain after nerve injury (Kehlet et al., 2006) and although only a handful of genetic polymorphisms have been identified that confer either an enhanced susceptibility to development of neuropathic pain, it is nevertheless clear that genotype is a substantial c”
• Neuropathic Pain (2009, background): “This transition to chronicity is most obvious after surgical nerve lesions where the extent and timing of the lesion are defined (Kehlet et al. 2006).”
• Prevalence of chronic pain with neuropathic characteristics in the general population (2008, neutral): “…Davies et al., 2006), multiple sclerosis (Osterberg et al., 2005), spinal cord injury (Siddall et al., 2003), stroke (Andersen et al., 1995), HIV infection (Hewitt et al., 1997), cancer (Caraceni and Portenoy, 1999) and persistent postsurgical pain (Kehlet et al., 2006) suffer neuropathic pain.”
• The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain (2019, neutral): “Regarding postsurgical pain, data suggest an incidence, varying with the type of operation, from 5% to 85%.(36) Severe chronic postsurgical pain that negatively affects the patient’s quality of life is in the range of 2% to 15%.”
• Prediction of chronic post‐operative pain: Pre‐operative DNIC testing identifies patients at risk (2008, methodology): “While the first reflects the pain modulation capabilities of the patient, the latter represents the tissue injury and inflammation induced by the surgical intervention [15].”
• Prevalence of and factors associated with persistent pain following breast cancer surgery. (2009, methodology): “Regarding pain and sensory disturbances, the women were asked systematically to address 4 specific regions of symptoms: (1) area of the breast (defined as either the affected breast or the area from which the breast was removed), (2) the axilla, (3) the arm, and (4) the side of the body, rating pain”
• RELIEVING PAIN IN AMERICA: A BLUEPRINT FOR TRANSFORMING PREVENTION, CARE, EDUCATION, AND RESEARCH (2012, background): “Between 10 and 50 percent of people having common surgical operations— groin hernia repair, breast and thoracic surgery, leg amputation, and coronary artery bypass surgery—go on to experience chronic pain, often due to damage to nerves in the surgical area during the procedure (Kehlet et al., 2006).”