In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer.

By Franck Pagès, A. Kirilovsky, Bernhard Mlecnik, M. Asslaber, M. Tosolini, Gabriela Bindea, C. Lagorce, P. Wind, F. Marliot, P. Bruneval and 5 more. Journal of Clinical Oncology, 2009

948 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/1f3899838072d7956782c3c2fc48e5cbc02bc807

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In Immunology

In Oncology

Citations in the corpus

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors (2014, background): “In early-stage colon cancer, 830 Immunity 41, 830–842, November 20, 2014 ª2014 Elsevier Inc. the presence of effector-memory CD8+ T cells has powerful prognostic importance, having been reported to bemore predictive of outcome than tumor-node-metastasis (TNM) stage (Pagès et al., 2009).”
Clinical significance of tumor-infiltrating lymphocytes in breast cancer (2016, background): “Infiltration of immune cells, particularly infiltration of anti-tumor type 1 lymphocytes, has predicted improved prognosis in many different tumor types including colon, ovarian, lung and breast cancer [1 – 4].”
Immune infiltration in human tumors: a prognostic factor that should not be ignored (2010, background): “In our own experience, however, we found no modification of the immune contexture of colorectal tumors in patients who received preoperative, neoadjuvant chemotherapy (Pages et al., 2009).”
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions (2013, background): “3d-g) [5, 6], suggesting they reflect persistent (epi-)genetic features of tumour cells rather than differences in stroma or immune infiltrate, which have been used previously as well to stratify patients [7, 8].”
Cancer heterogeneity—a multifaceted view (2013, positive): “Altogether, these and other studies [55] have demonstrated the impact of the TME on the heterogeneity of tumours.”
Immune parameters affecting the efficacy of chemotherapeutic regimens (2011, background): “The cell type that exhibits the highest positive correlation with patient survival is the memory effector T cell (CD45RO + CCR7 − , CD28 + CD27 + )”
The immune contexture in human tumours: impact on clinical outcome (2012, background): “An important clinical translation of this body of observations is the establishment of an immune score to determine the prognosis of clinical outcome in patients when there is no cancer-associated prognostic marke”