Immune parameters affecting the efficacy of chemotherapeutic regimens

By L. Zitvogel, Oliver Kepp, Guido Kroemer. Nature Reviews Clinical Oncology, 2011

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Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. (2013, background): “Immunostimulation via Effects on Cancer Cells Tumor debulking by surgery, radiotherapy, or chemotherapy obviously reduces the systemic immunosuppressive activity of malignant cells (Zitvogel et al., 2011).”
Immune Checkpoint Blockade in Cancer Therapy. (2015, background): “Although traditionally considered immunosuppressive, several preclinical studies indicate that chemotherapy may have immunostimulatory properties, as reviewed by Zitvogel et al.91 Some trials in patients with non–small-cell lung cancer and melanoma showed that combinations of chemotherapy with ipili”