Intensive insulin therapy in the medical ICU.

By G. Van den Berghe, A. Wilmer, G. Hermans, W. Meersseman, P. Wouters, I. Milants, E. Van Wijngaerden, H. Bobbaers, R. Bouillon. New England Journal of Medicine, 2006

3,366 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/3d2bbe570ae9f6da91072d1c462fdf71ae2e31a8

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In Endocrinology, Diabetes and Metabolism

In Pulmonary and Respiratory Medicine

Citations in the corpus

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 (2007, methodology): “A second randomized trial of intensive insulin therapy using the Leuven protocol enrolled medical ICU patients with an anticipated ICU LOS of 3 days in three medical ICUs (206).”
Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes Undergoing General Surgery (RABBIT 2 Surgery) (2011, background): “…setting, observational and prospective clinical trials have shown that hyper-glycemia is associated with increased rates of hospital complications and mortality (8,10,11) and that improved glycemic control reduces multiorgan failure, systemic infections, and short-and long-term mortality (7,8).”
Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. (2010, methodology): “tion of renal replacement therapy was assessed by cumulative hazard estimates and adjusted Cox proportional hazard analysis, censoring for early deaths (34).”
Standards of Medical Care in Diabetes—2008 (2008, result): “A subsequent study of a similar intervention in patients in a medical ICU (MICU) (290) showed that the group receiving intensive insulin therapy had reduced morbidity but no difference in mortality overall.”
American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control (2009, background): “Nevertheless, recent attempts to achieve tight glycemic control either have not reduced or have actually increased mortality in multicenter trials and clearly led to higher rates of hypoglycemia (13,14,16).”
Ill Adults: A Meta-analysis Benefits and Risks of Tight Glucose Control in Critically (2010, methodology): “The study participants encompass a broad distribution of adult ICU patients, as indicated by the variety of mean ages (46-75 years), distributions by sex (31%-95% men), proportions of patients with diabetes (0%100%), and degree of disease severity as measured by mean Acute Physiology and Chronic Hea”
Therapeutic hypothermia and controlled normothermia in the intensive care unit: Practical considerations, side effects, and cooling methods* (2009, background): “This requires active management because hyperglycemia may adversely affect outcome in critically ill patients (123, 124).”
Glycemic variability: A strong independent predictor of mortality in critically ill patients* (2008, neutral): “The first Leuven study, performed in a surgical ICU, is widely considered to be more “positive” in support of intensive glycemic management than is the second, completed in a medical ICU (10, 11, 30).”
A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study (2009, methodology): “The proportion of time in range calculated from morning BG values was not lower than in the most of the other studies [6, 7, 13, 17].”