Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.

By T. Jansen, J. van Bommel, F. J. Schoonderbeek, S. Sleeswijk Visser, J. M. van der Klooster, A. Lima, Sten P. Willemsen, J. Bakker. American Journal of Respiratory and Critical Care Medicine, 2010

809 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/5841160537ba337b1ab7c0b97791acb79d7b3779

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

In Epidemiology

Citations in the corpus

The demise of early goal‐directed therapy for severe sepsis and septic shock (2015, background): “This recommendation is based on the notion that an elevated lactate is a consequence of tissue hypoxia and inadequate oxygen delivery,(33) and is ‘supported’ by two studies that used ‘lactate clearance’ as the target of resuscitation.(34,35) However, the concept that sepsis is associated with tissue”
Etiology and therapeutic approach to elevated lactate levels. (2013, methodology): “Previous studies have attempted to use lactate clearance in a more specific manner using a protocol-driven response to persistent elevation.(145,146) Jansen et al(146) studied intensive care unit patients with presumed anaerobic causes of lactate levels of 3 mmol/L or greater and randomized them to ”
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 (2013, methodology): “center randomized trials evaluated a resuscitation strategy that included lactate reduction as a single target or a target combined with ScvO2 normalization [35, 36].”