Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling.

By G. Reid, M. Hübner, R. Métivier, H. Brand, S. Denger, Dominique Manu, J. Beaudouin, Jan Ellenberg, F. Gannon. Molecules and Cells, 2003

776 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3ccc53bf2faaa0bd0f620d2b086cb20485866fbb

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Citations in the corpus

Transcriptional pulsing of a developmental gene. (2006, background): “The pulsing is irregular, contrasting the periodic associations of transcriptional components with ER-responsive genes [22] and oscillations in RNA levels observed in E.”
Overview of Nomenclature of Nuclear Receptors (2006, background): “…recovery after photobleaching (FRAP) have revealed the dynamic and the cyclic nature of gene expression controlled by NRs. ChIP analyses of promoter occupancy by different NRs have shown a cyclic turnover of NRs on regulated promoters (Shang et al., 2000; Kang et al., 2002; Reid et al., 2003).”
Nuclear retinoid receptors and the transcription of retinoid-target genes. (2004, background): “Such a dual role may regulate the dynamic assembly/disassembly of retinoid receptors to the promoter of the target genes, as recently demonstrated for other nuclear receptors such as the estrogen and androgen receptors (Freeman and Yamamoto, 2002; Kang et al., 2002; Reid et al., 2003).”
Transcriptional complexes engaged by apo‐estrogen receptor‐α isoforms have divergent outcomes (2004, methodology): “In the presence of E2, cyclic clearance of the pS2 promoter of transcription factors is generated by (i) proteasomemediated degradation of ERa through recruitment of the APIS complex (Reid et al, 2003); and (ii) recruitment of HDACs-SWI/SNF and NuRD complexes (Métivier et al, 2003).”
Estrogen-receptor-α exchange and chromatin dynamics are ligand- and domain-dependent (2006, methodology): “Whereas FRAP data from our lab (Stenoien et al., 2001b) and others ( Reid et al., 2003 ) have shown that intra-nuclear mobility of ER is regulated by ligand, proteasome function or ATP, these data reflect the sum of multiple interactions in the nuclear volume that contains (spatially) few ER target ”
Coregulator function: a key to understanding tissue specificity of selective receptor modulators. (2004, background): “In this regard, MG132 blocks association of the phosphorylated RNA polymerase II with the pS2 gene promoter in MCF-7 cells, and also reduces the frequency with which ER and other factors cycle off and on this promoter in response to estradiol treatment (252).”
Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines (2010, background): “…ER [expressed in the striatum (Kipp et al., 2006; Schultz et al., 2009)] and its associated coactivators and repressor proteins (Alarid et al., 1999); it is also required for efficient ER -dependent transactivation and transcription (Lonard et al., 2000; Métivier et al., 2003; Reid et al., 2003).”
Elongation by RNA polymerase II: the short and long of it. (2004, background): “Several independent studies linked nuclear hormone receptor regulation to the 19S regulatory particle, although in a manner that required proteosome-mediated degradation (Gianni et al. 2002; Reid et al. 2003; Perissi et al. 2004).”