Genetic reconstruction of a functional transcriptional regulatory network

By Zhanzhi Hu, Patrick J. Killion, V. Iyer. Nature Genetics, 2007

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How researchers see this paper

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Reconstruction of Biochemical Networks in Microbial Organisms (2008, background): “Expression profiling studies of strains in which specific transcription factors have been delete”
Protein networks in disease. (2008, background): “In yeast, genetic perturbations have been profiled by expression profiling of gene knockout strains (Hughes et al. 2000; Workman et al. 2006; Hu et al. 2007 ) or by analysis of expression quantitative trait loci (eQTLs) (Brem and Kruglyak 2005), which identifies associations between polymorphic gen”
Wisdom of crowds for robust gene network inference (2012, methodology): “For S. cerevisiae, we considered several alternative gold standards derived from orthogonal datasets, namely ChIP binding data and evolutionary conserved transcription factor binding motifs 18 , as well as systematic transcription factor deletions 54 (Supplementary Note 3).”