Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes.

By M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, R. Paschke. Biochemical and Biophysical Research Communications - BBRC, 2002

690 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/3c74b18b0d99b63aed024c6e720550754bd961d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Jaswinder K. Sethi
2. W. Cawthorn

In Physiology

1. G. De Pergola
2. Jaswinder K. Sethi
3. F. Silvestris
4. W. Cawthorn

Citations in the corpus

• Obesity as a Major Risk Factor for Cancer (2013, background): “However, adiponectin serum levels correlate negatively with BMI and even more negatively with visceral adiposity [78] while insulin and estrogens may suppress its secretion [79].”
• The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. (2003, neutral): “Incubation of adipocytes with TNF-α markedly decreased expression of adiponectin (49).”
• Adiponectin Regulation and Function (2018, neutral): “Hydroxylation and subsequent glycosylation by a glucosyl α (1-2) galactosyl group occurs on four conserved lysine residues (mouse: Lys-68, 71, 80, and 104/human: Lys-65, 68, 77, and 101) in the collagenous domain of adiponectin, each having the surround motif of GXKGE(D) (270, 356, 359).”
• Adiponectin: action, regulation and association to insulin sensitivity (2005, background): “(71) showed a dose- and time-dependent inhibition of 3T3-L1 adipocyte adiponectin mRNA levels with a significant reduction after 4 h.”
• Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. (2003, background): “that TNF- in 3T3-L1 adipocytes (13) and in human”
• TNF-α and adipocyte biology (2007, background): “TNF-α may therefore induce systemic insulin resistance and dyslipidaemia by suppressing the production of adiponectin [63,109-111]; indeed, circulating levels of adiponectin inversely correlate with plasma levels of TNF-α [112,113].”