Role of PFKFB3-driven glycolysis in vessel sprouting.

By Katrien de Bock, M. Georgiadou, Sandra Schoors, Anna Kuchnio, B. Wong, A. Cantelmo, Annelies Quaegebeur, B. Ghesquière, S. Cauwenberghs, G. Eelen and 33 more. Cell, 2013

1,416 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1d79cb6984d90c2f04dca5ac3f77c7601b16f917

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In Molecular Biology

1. Rakesh K. Jain
2. N. Ferrara
3. Peter Carmeliet
4. Dai Fukumura
5. K. Alitalo
6. J. Joyce
7. R. Kerbel
8. Lance L. Munn

Citations in the corpus

• Understanding the intersections between metabolism and cancer biology (2017, neutral): “Endothelial cells also undergo factor-induced metabolic reprogramming, and metabolic therapies can limit endothelial cell proliferation and angiogenesis (De Bock et al., 2013).”
• Diabetic vascular diseases: molecular mechanisms and therapeutic strategies (2023, background): “EC are extensively damaged in DPDs, and EC produce ATP mainly by glycolysis.(370) In hyperglycemic states, changes in the metabolic pathways of sugar (increased flux of the hexosamine pathway, increased flux of the polyol pathway, decreased flux of pentose phosphate and glycolytic pathways) lead to ”
• Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies (2021, background): “During glycolysis, 85% of ATP is produced via converting glucose to lactate with the help of 6-phosphofructo2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) enzyme (De Bock et al., 2013).”
• Consensus guidelines for the use and interpretation of angiogenesis assays (2018, background): “Indeed, ECs are highly glycolytic, producing large amounts of ATP and lactate even in the presence of ample oxygen [170].”
• Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions (2015, background): “Very recently, however, a metabolic switch to aerobic glycolysis has been linked to more specialized–independent of proliferation–cell functions, such as interferon-gamma (IFNγ) production in T cells [29] and vessel sprouting in endothelial cells [41].”