Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.

By S. Broughton, M. Piper, Tomoatsu Ikeya, T. Bass, J. Jacobson, Yasmine Driege, P. Martinez, E. Hafen, D. Withers, S. Leevers and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2005

818 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/3c16c4a20b97b953e2211a3d650a1f27755f98ea

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides (2010, methodology): “Targeted ablation of the MNCs during early larval development results in developmental delay, growth defects and elevated carbohydrate levels in the larval hemolymph [10], while later ablation, during the final larval stage, results in lower female fecundity, increased storage of lipids and carbohyd”
Neural mechanisms of ageing and cognitive decline (2010, background): “Furthermore, ablation in the fly brain of specific neurosecretory cells that produce insulin-like peptides is sufficient to extend lifespa”
The plasticity of aging: insights from long-lived mutants. (2005, background): “Second, in worms and flies, reducing the activity levels of insulin-like peptides, like reducing receptor activity, can extend life span (Broughton et al., 2005; Li et al., 2003; Murphy et al., 2003; Wessells et al., 2004).”
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity (2011, neutral): “…(Arantes-Oliveira et al., 2002; Hsin and Kenyon, 1999); restoration or reduction of insulin/IGF-1 signaling (IIS) in neuronal or fat tissues (Broughton et al., 2005; Hwangbo et al., 2004; Kapahi et al., 2004; Libina et al., 2003; Wolkow et al., 2000); and genetic manipulations to specific…”
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster (2010, background): “Rapamycin treatment of flies with reduced levels of Drosophila insulin-like peptides (DILPs) due to the partial ablation of the DILP-producing median neurosecretory cells (mNSC) (Broughton et al., 2005) did not further increase life span in these long-lived flies (Figure 6B).”