Haematopoietic stem cell release is regulated by circadian oscillations

By S. Méndez-Ferrer, D. Lucas, M. Battista, P. Frenette. Nature, 2008

1,294 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/3bfda42d10f93cbc424af838a118234a876a144d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. J. Takahashi
2. C. H. Ko
3. Jan Born
4. Erin L. McDearmon
5. Heekyung Hong

In Physiology

1. J. Takahashi
2. Peter Libby
3. C. H. Ko
4. Luciana Besedovsky
5. S. Morrison
6. T. Lange
7. Shenghui He

In Pulmonary and Respiratory Medicine

1. Ralph Weissleder
2. Lee Josephson
3. Isaac Koh
4. Vasilis Ntziachristos
5. D. Hanahan
6. Lisa M. Coussens
7. Ron M. A. Heeren
8. Liam A. McDonnell

Citations in the corpus

• Sleep and immune function (2011, background): “In addition to nadir glucocorticoid levels, other factors like high levels of GH and low SNS activity could contribute to the accumulation of lymphocytes in lymph nodes during early sleep [57, 90, 104, 117].”
• Rhythmic modulation of the hematopoietic niche through neutrophil clearance (2013, positive): “Particularly fitting with this prediction are the natural circadian variations in CXCL12 levels in the BM which correlate with the rhythmic egress of HSPC into blood (Mendez-Ferrer et al., 2008).”
• Chronic variable stress activates hematopoietic stem cells (2014, positive): “Linking the autonomic nervous system and leukocyte trafficking, the β 3 adrenergic receptor expressed on niche cell surfaces regulates CXCL12 release 16 .”
• Mechanisms of stem cell self-renewal. (2009, background): “For unknown reasons, HSCs are regularly mobilized from the bone marrow though the circulation (Wright et al. 2001) according to circadian rhythms (Mendez-Ferrer et al. 2008).”
• Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche (2011, methodology): “These results were further confirmed using other conditional depletion models of mononuclear phagocytes, including transgenic mice expressing the diphtheria toxin (DT) receptor under the CD11b promoter (CD11b-DTR; Sympathetic neural tone is crucial for both steady state (Méndez-Ferrer et al., 2008) ”
• The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “Indeed, recent work demonstrates that even haematopoietic stem-cell release is regulated by the circadian clock and that the efficacy of stem-cell transplantation can vary by as much as twofold to threefold depending on the time of da”