Looping and interaction between hypersensitive sites in the active beta-globin locus.

By B. Tolhuis, Robert-Jan Palstra, Erik Splinter, Frank G. Grosveld, W. de Laat. Molecules and Cells, 2002

1,442 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3bfcbff335913835dac5dd144d440591386cd372

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Citations in the corpus

Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators (2011, neutral): “The notion that a given regulatory region can control multiple genes is well established, but past experimental analysis has largely focused on clusters of related genes such as the b -globin locus (Tolhuis et al., 2002) or tandem arrays of interleukin genes (Loots et al., 2000).”
Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. (2006, methodology): “…of yeast chromosome III (Dekker et al. 2002) and has since been applied to the analysis of several mammalian loci such as the -globin locus (Tolhuis et al. 2002; Palstra et al. 2003; Vakoc et al. 2005), the T-helper type 2 cytokine locus (Spilianakis and Flavell 2004), the immunoglobulin…”
Mechanism of Action of a Distal NF-κB-Dependent Enhancer (2006, methodology): “To explore this possibility, the 3C assay (22, 34, 57 , 58) was developed for the MCP-1 gene (Fig. 1A) using NIH 3T3 cells, which are highly inducible for MCP-1 expression (25, 48–50).”
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops (2004, methodology): “We then validated our observations independently using the chromosome conformation capture (3C) assa”
The β-globin nuclear compartment in development and erythroid differentiation (2003, methodology): “Here we analyze the structure of an erythroid-specific spatial cluster of cis -regulatory elements and active β-globin genes, the active chromatin hub (ACH; ref”
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. (2014, background): “…18 kbCTSPhysically Interact A hallmark of distal enhancer elements is their engagement in chromatin loops physically contacting with promoters to induce transcription factor assembly and polymerase II recruitment (Deng et al., 2012; Sanyal et al., 2012; Thurman et al., 2012; Tolhuis et al., 2002).”
Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions (2007, background): “For instance, interactions between the locus control region (LCR) and downstream regulatory elements at the β-globin locus drive the formation of a 200-kb loop, specifically in expressing cell”
A three-dimensional map of the human genome at kilobase resolution reveals principles of chromatin looping (2014, result): “These observations are consistent with the classic model in which looping between a promoter and enhancer activates a target gene (Tolhuis et al., 2002; Amano et al., 2009; Ahmadiyeh et al., 2010).”