Alternative pre-mRNA splicing: the logic of combinatorial control.

By Christopher W. J. Smith, J. Valcárcel. TIBS -Trends in Biochemical Sciences. Regular ed, 2000

962 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3bd0058fb4c4f68d575f7a4e05e195b8df19b979

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In Molecular Biology

Citations in the corpus

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches (2009, background): “ISSs and ESSs are commonly bound by heterogeneous nuclear RNPs (hnRNPs; Table 1 ), which have one or more RNA-binding domains and protein–protein interaction domain”
A genomic view of alternative splicing (2002, background): “Its regulatory mechanisms have recently been discovered in several gene”
Function of alternative splicing. (2005, positive): “The accurate recognition of splice sites in vivo is the result of a combinatorial regulatory mechanism (Smith and Valcarcel, 2000).”
Nuclear Pre-mRNA Splicing in Plants (2001, background): “Several factors such as the cell type, developmental stage of an organ or organism, or signals influence the processing path that a transcript takes (Smith and Valcarcel, 2000).”
The spliceosome: design principles of a dynamic RNP machine. (2009, background): “As previously discussed, these choices are determined by the combined actions of both positive and negative regulatory proteins and the contribution of splicing enhancer and silencer sequences (reviewed in Smith and Valcarcel, 2000).”
A census of human RNA-binding proteins (2014, background): “example, the abundance of various splicing factors can influence mRNA splicing patterns (Chen and Manley, 2009; Kalsotra and Cooper, 2011; Kornblihtt et al., 2013; Smith and Valcarcel, 2000; Wahl et al., 2009), while U1 snRNP levels control alternative polyadenylation sites (Berg”
Spliceosome structure and function. (2011, background): “For more in-depth reviews of alternative splicing and its regulation the reader is referred to several recent reviews (Chen and Manley 2009; Matlin et al. 2005; Black 2003; Smith and Valcárcel 2000).”
Fast-Find: A novel computational approach to analyzing combinatorial motifs (2006, background): “This combinatorial control is the rule rather than the exception in higher eukaryotes for critical processes including transcription [1] and splicing [2], and has also been observed in bacterial transcription [3].”
Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. (2006, background): “This strengthens the notion that more than one ESR regulates each splicing event (Smith and Valcarcel, 2000).”