Spliceosome structure and function.

By C. Will, Reinhard Lührmann. Cold Spring Harbor Perspectives in Biology, 2011

1,736 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0c223cb4fafd917692a5d9e9b7a660f07d0ec8a8

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In Molecular Biology

Citations in the corpus

Complexity of the Alternative Splicing Landscape in Plants[C][W][OPEN] (2013, background): “…of alternative splicing (AS) in plant development came from differential expression of Ser/Arg-rich (SR) protein splicing factors in different organs and during development (Lopato et al., 1996, 1999b; Kalyna et al., 2003; Palusa et al., 2007) indicating organ-specific regulation of AS in plants.”
The spliceosome: design principles of a dynamic RNP machine. (2009, background): “, 2002), have led to the hypothesis that the spliceosome can also exist in a more extensively preassembled form selection, and glycerol gradient centrifugation), landmark assembly intermediates are operationally defined by the sequential association and release of the spliceosomal snRNPs (reviewed i”
Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing (2019, background): “Most RNA polymerase II (RNA pol II) transcripts are processed by the spliceosome, a large complex assembled from five subunits (U1, U2, U4, U5 and U6) each consisting of multiple proteins and an RNA scaffold (1).”
Mechanisms and Regulation of Alternative Pre-mRNA Splicing (2015, background): “Recall that the BΔU1 complex represents a precatalytic spliceosome and differs significantly in protein composition from the activated Bact/B* spliceosome (12).”
Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses[OPEN] (2013, background): “It consists of five small nuclear ribonucleoprotein particles (snRNPs) and over 200 additional proteins (Wahl et al., 2009; Will and Lührmann, 2011; Koncz et al., 2012; Reddy et al., 2013).”
A Protein Complex Network of Drosophila melanogaster (2011, background): “Each snRNP consists of one or two snRNAs, a commonset of sevenSm (or LSm)proteins, andavariable number of unit-specific proteins (Will and Lührmann, 2011).”
The nuts and bolts of the endogenous spliceosome (2017, background): “Namely, the nascent pre-mRNA is assembled into supraspliceosomes during transcription, whereas the assembly process in vitro occurs when a full-length pre-mRNA is interacting with the spliceosomal components present in a nuclear extract.(2) These two likely distinct pathways may lead to different lo”