Dietary polyunsaturated fatty acids and inflammatory mediator production.

By M. James, R. Gibson, L. Cleland. American Journal of Clinical Nutrition, 2000

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Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. (2009, background): “aspirin, or by increasing n 3 fatty acid content, particularly EPA and DHA [234].”
Prostate cancer and inflammation: the evidence (2012, background): “A major constituent of dietary polyunsaturated fats in western diets are n-6 fatty acids, primarily in the form of linoleic acid (LA).(80) LA is metabolized into arachidonic acid, which can in turn be transformed into the proinflammatory eicosanoids prostaglandin E2 (PGE2) and leukotriene B4 (LTB4).”
Dry eye disease: an immune-mediated ocular surface disorder (2012, background): “Downloaded From: https://jamanetwork.com/ on 08/24/2022 racycline derivative doxycycline can inhibit c-Jun Nterminal kinase and extracellular signal–related kinase mitogen-activated protein kinase signaling in epithelial cells of the ocular surface exposed to hyperosmolar stress, downregulating the ”
An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity (2016, background): “Inflammation AA metabolites prostaglandin 2 thromboxane 2 and leukotriene 4 are prothrombotic and proinflammatory leading to increased production of IL-1, IL-6, NFKB and TNF and inflammation [1,64].”