Triglyceride accumulation protects against fatty acid-induced lipotoxicity

By Laura L. Listenberger, Xianlin Han, Sarah E. Lewis, S. Cases, Robert V Farese, D. Ory, J. Schaffer. Proceedings of the National Academy of Sciences of the United States of America, 2003

2,022 citations recorded by the source corpus.

Subfields: Biochemistry, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/3b58d8d1cc86677aae0028f7785951186b4ead6a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Douglas P Lee
2. R. Coleman
3. A. Schulze
4. G. Hotamışlıgil
5. M. Alves‐Bezerra
6. David E Cohen

In Physiology

1. Brent R. Stockwell
2. Karine Clément

In Surgery

1. Douglas P Lee
2. Brent R. Stockwell
3. R. Coleman

Citations in the corpus

• Cardiac Metabolism and Its Interactions with Contraction, Growth, and Survival of the Cardiomyocte (2013, background): “Interestingly, coincubation with the unsaturated fatty acid, oleate, significantly reduced apoptosis measures in cells.(212,215,216) Because the metabolic rate of quiescent cells is vastly different from that of”
• Enzymes of triacylglycerol synthesis and their regulation. (2004, background): “Similarly, 16:0-induced apoptosis of CHO and mouse embryonic fibroblast cells is achieved independent of ceramide production; and adding 18:1 to the media increases 16:0 incorporation into TAG and protects against apoptosis [279,280].”
• Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State (2019, positive): “We find that ACSL3 is required for exogenous MUFAs to protect cells against ferroptosis, but not lipotoxicity induced by exogenous SFAs.”
• Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration (2015, positive): “These stresses promote damage to neurons and glia and contribute to the demise of neurons (Barnham et al., 2004; Listenberger et al., 2003).”
• Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. (2006, background): “Oleic acid rescued palmitateinduced apoptosis in CHO cells (21).”
• Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes (2007, background): “The differential cytotoxicity of saturated and unsaturated fatty acids has been extensively reported using beta cells [6, 23–26], although not in one study, where both oleate and palmitate triggered ER stress in INS-1E cells [17].”
• Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients (2012, background): “Experimental studies have shown that triglycerides themselves are not toxic and may in fact protect the liver from lipotoxicity by buffering the accumulation of fatty acids.(29,30) Indeed, patients with rare genetic diseases display massive steatosis but will not develop inflammation or fibrosis, as”
• Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model (2019, background): “The increased TAG pool might serve as a buffer against lipid peroxidation induced by IKE (Listenberger et al., 2003).”
• Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. (2014, background): “In our work, the addition of oleate protected against ROS cytotoxicity, as channeling of saturated FAs toward TGs stored in LDs directed free FAs away from pathways that lead to ROS production (Listenberger et al., 2003).”