Mechanism of eukaryotic homologous recombination.

By J. San Filippo, P. Sung, H. Klein. Annual Review of Biochemistry, 2008

1,683 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3b33dc9f2fa28694e7eda381b23f755deda687db

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In Cell Biology

1. A. Sica
2. P. Allavena
3. F. Colotta
4. C. Garlanda
5. Stephen P. Jackson
6. Rodney Rothstein
7. W. Chung
8. G. Ira

In Molecular Biology

1. Stephen P. Jackson
2. S. Polo
3. A. Sica
4. P. Allavena
5. J. R. Chapman
6. B. Kaina
7. W. Roos
8. S. Boulton

Citations in the corpus

• CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes (2015, background): “This lack of bi-directional sequence exchange supports the notion that the HBB gene was repaired primarily through non-crossover HDR (San Filippo et al., 2008).”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “There are two major mechanisms for DSB repair, homologous recombination (HR) [165] and non-homologous end-joining (NHEJ) [166].”
• Regulation of homologous recombination in eukaryotes (2010, background): “Finally, in postsynapsis, the three subpathways of HR are distinguished (Figure 1), each with specific enzymatic requirements that have been only partially defined (69, 91, 129, 161).”
• Chapter 1. General introduction (2015, positive): “SDSA is based on mitotic DSB repair data in model organisms (25) and is thought to be the predominant mechanism”
• Homologous recombination and its regulation (2012, background): “Although BRCA2 has no homology with yeast Rad52, BRCA2 is its functional equivalent since it controls the assembly of human RAD51 into nucleoprotein filaments as demonstrated both in vivo and in vitro (15,176).”
• Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, background): “HR requires the presence of a homologous template, usually a sister chromatid, which allows accurate repair of postreplicative DSBs in S and G2 phases of the cell cycle (San Filippo et al. 2008; Moynahan and Jasin 2010).”
• Repair of strand breaks by homologous recombination. (2013, background): “Critical mediators are Rad52 in yeast and BRCA2 in mammalian cells, as Rad51 recruitment to DSBs, and hence HR, are substantially impaired when these proteins are disrupted (Sugawara et al. 2003; Lisby et al. 2004; San Filippo et al. 2008; Moynahan and Jasin 2010).”
• DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. (2013, background): “ports it to the lesion, partially denatures the DNA, initiates and executes DNA synthesis at the intact matrix, separates the DNA strands and restores the undamaged and intact DNA [111].”
• Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double strand break ends (2008, positive): “The strand exchange protein Rad51 assembles a nucleofilament at 3 0 ssDNA tails that carries out a search for homologous sequences and promotes strand invasion (reviewed in San Filippo et al., 2008; Symington, 2002).”