The grateful dead: damage‐associated molecular pattern molecules and reduction/oxidation regulate immunity

By Michael Lotze, H. J. Zeh, A. Rubartelli, L. J. Sparvero, A. Amoscato, Newell Washburn, M. Devera, X. Liang, M. Tör, Timothy R. Billiar. Immunological Reviews, 2007

655 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Immunology

View Paper: https://www.semanticscholar.org/paper/3b2d602c82a89208ad0977c359f9c47d67b11839

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In Clinical Biochemistry

1. Kevin J. Tracey
2. U. Andersson
3. Shizuo Akira

In Immunology

1. Kevin J. Tracey
2. U. Andersson
3. Shizuo Akira
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Citations in the corpus

• Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. (2012, background): “Other molecules, including those associated with cell death, are also known to have potent immunomodulatory effects [40, 41].”
• Costs and benefits of hormone-regulated plant defences (2013, background): “Similarly, recognition of socalled damage-associated molecular patterns (DAMPs), such as galacturonides, systemins and AtPep1, which are endogenous elicitors that accumulate as a result of enzymatic degradation of plant cell walls or proteins upon attack by pathogens or insects, leads to activation ”
• A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release (2010, background): “TNF, IL-1β, IL-6, IL-10, and MIP-2 released in the supernatants of macrophage cultures weremeasured by commercially available ELISA kits according to the instructions of the manufacturer (R&D Systems Inc.).”
• Of PAMPs and Effectors: The Blurred PTI-ETI Dichotomy[OA] (2011, background): “These danger signals are either molecules that are directly derived from the microbe (PAMPs and effectors) or represent microbial invasion-derived, damaged, or modified eukaryotic host structures that are not present or not released in noninfected organisms (Matzinger, 2002, 2007; Lotze et al., 2007”
• Cytokines in Radiobiological Responses: A Review (2012, positive): “A balanced measure of cellular selfsacrifice by stressed local tissue cells and by the inflammatory cells [the ‘‘grateful dead’’ (73)] contributes and lymphocytes and macrophages follow.”
• DAMPening Inflammation by Modulating TLR Signalling (2010, neutral): “• Atherosclerosis[235] • Diabetes [236] • Lupus [90, 115, 237] • Multiple sclerosis [119] • Rheumatoid arthritis [111] • Sepsis [114] • Sjogrens [238] • Systemic sclerosis [239] • Tumors inc breast, lung, colorectal, pancreatic, melanoma [9] HMGB1”
• Antibiotic resistance plasmids in wastewater treatment plants and their possible dissemination into the environment (2010, background): “Plants also respond to endogenous molecules released by pathogen invasion, such as cell wall or cuticular fragments called danger-associated molecular patterns (DAMPs) (Lotze et al., 2007; Matzinger, 2007; Zipfel et al., 2008; Postel and Kemmerling, 2009).”