A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
By Huan Yang, H. Hreggvidsdóttir, K. Palmblad, Haichao Wang, M. Ochani, Jianhua Li, Ben Lu, S. Chavan, M. Rosas‐Ballina, Y. Al-Abed and 5 more. Proceedings of the National Academy of Sciences of the United States of America, 2010
830 citations recorded by the source corpus.
Subfields: Clinical Biochemistry, Immunology
View Paper: https://www.semanticscholar.org/paper/ec2bcaaa1e94aaec4ada819597b6891822070e8d
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In Clinical Biochemistry
In Immunology
Citations in the corpus
- Apoptosis, autophagy, necroptosis, and cancer metastasis (2015, background): “Once released, HMGB1 activates dendritic cells by engaging Toll-like receptor 4, which triggers an intense antitumor immune response and restricts metastasis [79,80].”
- PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Interestingly, a cysteine at position 106 (Cys106) within HMGB1 is required for binding to TLR4 and activation of cytokine release in macrophages (75).”
- HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 (2012, background): “It is currently not known whether all receptors and all signaling pathways are required for the different responses to HMGB1; recent evidence suggests that TLR4 but not RAGE is required for cytokine release (Yang et al., 2010) and that RAGE is involved in cell migration (Penzo et al., 2010).”