MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK21

By J. Hou, Pin Wang, Li Lin, Xingguang Liu, Feng Ma, Huazhang An, Zhugang Wang, Xuetao Cao. Journal of Immunology, 2009

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Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. (2011, methodology): “Antibodies specific to phospho-ERK, phospho-p38, phospho-JNK, b-actin, and horseradish peroxidase-coupled secondary antibodies were described previously (An et al., 2008; Hou et al., 2009; Wang et al., 2009b).”
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses (2010, positive): “In the latter, miR-146a acts as a negative feedback regulator to limit TRAF6 and IRAK1/2-mediated signaling in inflammatory settings (Hou et al., 2009; Taganov et al., 2006), whereas in activated human T cells, miR-146a has been suggested to oppose apoptosis and IL-2 production (Curtale et al.,…”
microRNA regulation of inflammatory responses. (2012, background): “miR-146a is also induced during viral infection, pointing to a general role for this miRNA as a feedback negative regulator of the innate immune response (40).”
Coronavirus infections and immune responses (2020, background): “RIG-I/NF-κB-dependent pathway 45 and the disorder of the JAK-STAT signaling pathway directly affects the spread of virus.”